NAD + supplementation rejuvenates aged gut adult stem cells
| Autor: | Takashi Kadowaki, Eric O. Williams, Toshimasa Yamauchi, Frank Jaksch, Masaomi Miura, Masaki Igarashi, Leonard Guarente |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Aging medicine.medical_specialty Cell Biology mTORC1 Biology digestive system 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Endocrinology chemistry Internal medicine Nicotinamide riboside medicine NAD+ kinase biological phenomena cell phenomena and immunity Stem cell 030217 neurology & neurosurgery Ex vivo Adult stem cell |
| Zdroj: | Aging Cell. 18:e12935 |
| ISSN: | 1474-9726 1474-9718 |
| DOI: | 10.1111/acel.12935 |
| Popis: | The tissue decline due to aging is associated with the deterioration of adult stem cell function. Here we show the number and proliferative activity of intestinal stem cells (ISCs) but not Paneth cells decline during aging, as does ISC function assessed ex vivo. Levels of SIRT1 and activity of mTORC1 also decline with aging. The treatment with the NAD(+) precursor nicotinamide riboside (NR) rejuvenates ISCs from aged mice and reverses an impaired ability to repair gut damage. The effect of NR is blocked by the mTORC1 inhibitor rapamycin or the SIRT1 inhibitor EX527. These findings demonstrate that small molecules affecting the NAD/SIRT1/mTORC1 axis may guide a translational path for maintenance of the intestine during aging. |
| Databáze: | OpenAIRE |
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