Prediction and comparison of the secondary structure of legume lectins

Autor: M. Joginadha Swamy, M. Venkata Krishna Sastry, Avadhesha Surolia
Rok vydání: 1985
Předmět:
Zdroj: Journal of Biosciences. 9:203-212
ISSN: 0973-7138
0250-5991
DOI: 10.1007/bf02702696
Popis: Secondary structure prediction for the 4 legume lectins: Concanavalin A, soybean agglutinin, favabean lectin and lentil lectin, was done by the method of Chou and Fasman. This prediction shows that these four lectins fall into a structurally distinct class of proteins, containing high amounts of β-sheet and β-turns. There is a notable similarity in the gross structure of these proteins; all four of them contain about 40–50% of β-sheet, 35–45 % β-turn and 0–10% of α-helix. When the secondary structure of corresponding residues in each pair of these lectins was compared, there was a striking similarity in the Concanavalin A-soybean agglutinin and favabean lectin-lentil lectin pairs, and considerably less similarity in the other pairs, suggesting that these legume lectins have probably evolved in a divergent manner from a common ancestor. A comparison of the predicted potential β-turn sites also supports the hypothesis of divergent evolution in this class of lectins.
Databáze: OpenAIRE
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