Neural Stem Cells: Implications for the Conventional Radiotherapy of Central Nervous System Malignancies
| Autor: | Stanley H Benedict, Igor J. Barani, Peck Sun Lin |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Cancer Research
Radiation business.industry Dentate gyrus Neurogenesis Subventricular zone Neural stem cell Subgranular zone Neuroepithelial cell medicine.anatomical_structure nervous system Oncology Cancer stem cell Immunology medicine Radiology Nuclear Medicine and imaging Stem cell business Neuroscience |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 68:324-333 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2007.01.033 |
| Popis: | Advances in basic neuroscience related to neural stem cells and their malignant counterparts are challenging traditional models of central nervous system tumorigenesis and intrinsic brain repair. Neurogenesis persists into adulthood predominantly in two neurogenic centers: subventricular zone and subgranular zone. Subventricular zone is situated adjacent to lateral ventricles and subgranular zone is confined to the dentate gyrus of the hippocampus. Neural stem cells not only self-renew and differentiate along multiple lineages in these regions, but also contribute to intrinsic brain plasticity and repair. Ionizing radiation can depopulate these exquisitely sensitive regions directly or impair in situ neurogenesis by indirect, dose-dependent and inflammation-mediated mechanisms, even at doses |
| Databáze: | OpenAIRE |
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