OC-087 PAIN AND INFLAMMATORY SIGNALLING IN TACKOMESH TRIAL PARTICIPANTS FOLLOWING ELECTIVE LAPAROSCOPIC INCISIONAL HERNIA REPAIR WITH INTRAPERITONEAL ONLAY MESH (IPOM) AND SPIRAL-TACK MESH FIXATION
| Autor: | J Pilkington, F Wilkinson, J Pritchett, C Fullwood, A J Sheen |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | British Journal of Surgery. 109 |
| ISSN: | 1365-2168 0007-1323 |
| DOI: | 10.1093/bjs/znac308.097 |
| Popis: | Background The aim of this study was to investigate for links between reported pain and inflammation within a sub-cohort of patients undergoing the IPOM plus repair through the measurement of serum/plasma levels of established inflammatory biomarkers in trial participants across 1-year follow up. Methods 22 patients (12 Protack™ and 10 Reliatack™) within the TACKoMesh randomised controlled trial underwent serial blood sampling as part of their follow up. A panel of pro- and anti-inflammatory biomarkers were assayed using Luminex multiplex assays and ELISAs. Circulating biomarker concentrations were described and compared in the context of clinical and patient reported outcome data that was obtained within the trial. Results An increase in the serum concentration of pro- (IL-6 and CRP) and anti- (IL-10) inflammatory biomarkers was seen following IPOM plus repair. Serum IL-6 and CRP were significantly raised compared to baseline at post-operative Days 1, 6 and 30 (p < 0.05). Markers of onward signalling (Cortisol and TNF-alpha) and tissue repair (PDGF-AA and VEGF) showed a trend towards an elevation at similar timepoints (notably at post-op Day 6) but were not significantly different from baseline levels. There were no observed correlations between inflammatory signal and reported pain, treatment allocation within the trial, burden of implanted prosthetic material, or hernia recurrence. Discussion This study demonstrates the novel finding of a pro-inflammatory signal at post-operative Day 30 following the IPOM plus repair. |
| Databáze: | OpenAIRE |
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