Effect of the β2-adrenergic agonist clenbuterol on the growth of fast- and slow-twitch skeletal muscle of the dystrophic (C57BL6J ) mouse
| Autor: | P. A. Hatton, Anthony C. Wareham, R.H. Morton, E. T. Agbenyega |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pharmacology
medicine.medical_specialty Small diameter Fast twitch muscle Chemistry musculoskeletal neural and ocular physiology Immunology Skeletal muscle musculoskeletal system medicine.disease medicine.anatomical_structure Endocrinology Clenbuterol Internal medicine medicine Adrenergic agonist Muscular dystrophy Whole body Beta (finance) tissues medicine.drug |
| Zdroj: | Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. 111:397-403 |
| ISSN: | 0742-8413 |
| DOI: | 10.1016/0742-8413(95)00066-6 |
| Popis: | Clenbuterol (4mg/kg in diet for 21 days) had no statistically significant effect on whole body growth. It did cause a significant increase (18.2%) in wet weight of the fast twitch muscle extensor digitorum longus (EDL) and a corresponding 14.9% increase in total muscle protein. In transverse sections through dystrophic muscle fibre sizes were more variable than in normal muscle. Clenbuterol treatment resulted in a reduction in the proportion of small diameter fibres, and therefore an increase in mean fibre diameter, in dystrophic EDL. Clenbuterol had no significant effect upon the slow twitch muscle soleus. |
| Databáze: | OpenAIRE |
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