Tyrosinase Inhibitors from Anise Oil
| Autor: | Ikuyo Kinst-Hori, Isao Kubo |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
chemistry.chemical_classification
Schiff base biology Chemistry Stereochemistry Tyrosinase Biological activity General Chemistry law.invention chemistry.chemical_compound Enzyme Non-competitive inhibition Enzyme inhibitor law Pimpinella anisum biology.protein General Agricultural and Biological Sciences Essential oil Nuclear chemistry |
| Zdroj: | Journal of Agricultural and Food Chemistry. 46:1268-1271 |
| ISSN: | 1520-5118 0021-8561 |
| Popis: | Anisaldehyde characterized in the seeds of Pimpinella anisum L. (Umbelliferae), also known as aniseed, was found to inhibit the oxidation of l-3,4-dihydroxyphenylalanine (l-DOPA) by mushroom tyrosinase (EC 1.14.18.1) with an ID50 of 43 μg/mL (0.32 mM). The inhibition kinetics analyzed by a Lineweaver−Burk plot established anisaldehyde to be a noncompetitive inhibitor for this oxidation. On the basis of this finding, various related analogues were also tested in order to gain new insights into their structural functions. Keywords: Anisaldehyde; aniseed; tyrosinase inhibitor; l-DOPA; noncompetitive inhibition; Schiff base formation |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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