Geroprotective effects of ×Sorbaronia mitschurinii fruit extract on Drosophila melanogaster

Autor: Natalya R. Pakshina, Elena Platonova, Denis A. Golubev, Nadezhda Zemskaya, Mikhail V. Shaposhnikov, Sergey A. Patov, Vasily V. Punegov, Daria V. Kukuman, Alexey Moskalev, Natalia S. Ulyasheva
Rok vydání: 2022
Předmět:
Zdroj: Journal of Berry Research. 12:73-92
ISSN: 1878-5123
1878-5093
Popis: BACKGROUND: ×Sorbaronia mitschurinii (also known as Aronia mitschurinii) is an intergeneric hybrid of×Sorbaronia fallax and Aronia melanocarpa. ×S. mitschurinii berry is a rich source of phytochemicals such as flavonoids and anthocyanins, which have a broad range of health benefits and a great geroprotective potential. OBJECTIVES: The goal of the present study was to investigate the geroprotective effects of Sorbaronia berry ethanolic extract (SBE) in Drosophila melanogaster and whether these effects depend on the concentration of SBE, duration of treatment, age, and sex. METHODS: SBE was used to supplement a diet of Drosophila imagoes throughout life, during 2 weeks after the imago hatching, and from 4 to 6 weeks of age. The relationship between the SBE effects on lifespan, stress resistance and the expression of stress response genes were examined. RESULTS: SBE treatment at 1-2 and 4-6 weeks of life increased the lifespan, while treatment throughout life reduced lifespan. SBE treatment increased Drosophila resistance to oxidative stress and starvation, but not to hyperthermia. A statistically significant effect of SBE treatment on the expression level of per, keap1, hif1, hsp27, hsp68, hsp83, and sirt1 genes in flies of both sexes and on sod1 expression only in female flies was demonstrated. CONCLUSIONS: The observed relationship between SBE concentration and lifespan effects suggests that the life-extending effect of SBE may be associated with the mechanism of hormesis.
Databáze: OpenAIRE
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