Antitumor effects of the combination of magnetohydrodynamic thermochemotherapy and magnetic resonance tomography

Autor:	V. A. Polyanskii, A. V. Ivanov, T. I. Ksenevich, E. R. Vol’ter, Petr I. Nikitin, Maxim P. Nikitin, N. A. Brusentsov, A. A. Uchevatkin, Dmitry A. Kupriyanov, A. I. Dubina, D. A. Tishchenko, T. N. Brusentsova, Yu. A. Pirogov
Rok vydání:	2010
Předmět:	Pharmacology Antitumor activity Aqueous solution medicine.diagnostic_test Chemistry Mri negative Magnetic resonance imaging Colloid chemistry.chemical_compound Nuclear magnetic resonance Dextran Drug Discovery medicine Ferrite (magnet) Citric acid
Zdroj:	Pharmaceutical Chemistry Journal. 44:291-295
ISSN:	1573-9031 0091-150X
Popis:	Fe3O4 nanoparticles were coated with a layer of citric acid, forming coordination bonds between citrate ions and iron ions. The resulting aqueous citrate ferrite colloid was used as a T2-weighted MRI negative contrasting agent. Sequential i.v. doses of citrate ferrite and Magnevist led to increases in MRI image contrast for 40 h and brightness for 30 min; scanning using a Bruker Biospec BC 70/30 USR biospectrotomograph yielded enhanced MRI images. This enhancement of MRI images was used to monitor oncogenesis during magnetohydrodynamic thermochemotherapy (MT) of mammary adenocarcinoma Ca 755 in female C57Bl/6j mice. Dextran ferrite colloid containing cyclophosphamide was tested as a magnetically directed antitumor agent using MT. Treatment of non-infiltrating tumors of volume ≈ 30 mm3 with six sessions of MT each lasting 30 min at 46°C led to 40% tumor regression and 300% increases in survival time. Treatment of infiltrating tumors of volume ≈ 300 mm3 in the same conditions yielded a 200% increase in survival time.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ee5cf130245e39551f09a3db3e1b0dc5 https://doi.org/10.1007/s11094-010-0452-3 Zobrazit plný text záznamu Plný text ve formátu PDF