Taxol Semisynthesis: A Highly Enantio- and Diastereoselective Synthesis of the Side Chain and a New Method for Ester Formation at C-13 Using Thioesters

Autor:	Anna Vulpetti, Ermes Vanotti, Nicola Mongelli, Monica Donghi, Cesare Gennari, Michela Carcano
Rok vydání:	1997
Předmět:	chemistry.chemical_compound Addition reaction chemistry Docetaxel Paclitaxel Stereochemistry Organic Chemistry Imine medicine Side chain Combinatorial chemistry Semisynthesis medicine.drug
Zdroj:	The Journal of Organic Chemistry. 62:4746-4755
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo9703212
Popis:	A very simple, new, and straightforward approach to the Paclitaxel (Taxol) and Docetaxel (Taxotere) side chains has been developed using the imine addition reaction of thioester-derived boron enola...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ee59c04006223af6b08696424f38872c https://doi.org/10.1021/jo9703212 Zobrazit plný text záznamu