Study of the Interaction between Xmas-2, the Main Protein of TREX-2 mRNA Export Complex, and the Orc3 Protein, a Subunit of ORC Complex of D. melanogaster

Autor:	D. V. Kopytova, Sofia G. Georgieva, M. M. Kurshakova
Rok vydání:	2021
Předmět:	Messenger RNA biology Chemistry Protein subunit Biophysics General Chemistry General Medicine biology.organism_classification Biochemistry Cell biology medicine.anatomical_structure Cytoplasm Melanogaster medicine biology.protein Nuclear pore Protein A Peptide sequence Nucleus
Zdroj:	Doklady Biochemistry and Biophysics. 496:18-21
ISSN:	1608-3091 1607-6729
DOI:	10.1134/s1607672921010063
Popis:	The TREX-2 protein complex is the key participant in the export of mRNA from the nucleus to the cytoplasm through the nuclear pores. Previously, a protein complex of D. melanogaster consisting of TREX-2 and ORC complexes was purified. It was shown that, in the TREX-2-ORC complex, the Xmas-2 protein, which is the platform for TREX-2 assembly, interacts with the Orc3 protein. The aim of this work was to investigate what regions of the Xmas-2 amino acid sequence are involved in the interaction with Orc3. It was shown that the interaction of Xmas-2 with Orc3 requires a C-terminal region of Xmas-2 located downstream of the CID domain.
Databáze:	OpenAIRE
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