Synthesis and Antiradical and Antibacterial Activity of 4-(3′,4′-Dihydroxyphenyl)Thiazole Derivatives

Autor:	N. I. Burakov, L. V. Kanibolotskaya, E. N. Poddubnaya, N. Yu. Lebedeva, A. L. Kanibolotskii, A. N. Shendrik, V. V. Odaryuk, I. D. Odaryuk
Rok vydání:	2015
Předmět:	Pharmacology chemistry.chemical_classification Catechol Antimicrobial Corpus albicans chemistry.chemical_compound chemistry Toxicity class Drug Discovery Toxicity Organic chemistry Antibacterial activity Thiazole Thioamide
Zdroj:	Pharmaceutical Chemistry Journal. 49:96-98
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-015-1229-5
Popis:	A series of dihydroxyphenylthiazoles were synthesized via the reaction of 4-(chloroacetyl)catechol with thioamide derivatives. Their antiradical activity was studied using the reaction with the cation-radical 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid). Antimicrobial activity of the dihydroxyphenylthiazoles was studied against P. aeruginosa, C. albicans, S. epidermidis, and S. aureus. These compounds were found to belong to toxicity class 4.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ee3f125ba2923fd354eff7105bf94f96 https://doi.org/10.1007/s11094-015-1229-5 Zobrazit plný text záznamu Plný text ve formátu PDF