Epstein-Barr virus (EBV) in Chinese pediatric Hodgkin disease

Autor: Xiao Long Ji, Pei Juan Li, Stephen J. Hamilton-Dutoit, Kristian Sandvej, Ji Ping Da, Xiao Ge Zhou, Qing Han Yan, Xiao Ping Zhang
Rok vydání: 2001
Předmět:
Zdroj: Cancer. 92:1621-1631
ISSN: 1097-0142
0008-543X
DOI: 10.1002/1097-0142(20010915)92:6<1621::aid-cncr1488>3.0.co;2-p
Popis: BACKGROUND The Epstein-Barr virus (EBV) is thought to be involved in the pathogenesis of some Hodgkin disease (HD) cases. EBV may be associated particularly with childhood HD, a disease rare in the West compared with developing countries. In this study, a large series of Chinese pediatric HD cases has been examined to determine the age-specific prevalence of EBV. METHODS Paraffin sections from 104 pediatric and 52 adult Chinese HD cases were examined for EBV-RNA (EBERs) and EBV latent membrane protein-1. RESULTS Most pediatric cases arose in boys and showed an histology of mixed cellularity. Prominent interfollicular involvement was seen frequently in the childhood cases. EBV was identified in tumor cells in 113 of 156 (72%) HD cases but was more frequent in pediatric cases (93 of 104; 89%) compared with adult cases (20 of 52; 38%) (P 0.05; chi-square test). Pediatric HD was associated with EBV irrespective of histologic subtype. In adults, EBV was associated more frequently with mixed cellularity than with other subtypes. CONCLUSION To the authors' knowledge, this is to date the largest series of pediatric HD cases studied for EBV. Study findings provided further evidence that HD is etiologically heterogenous. The authors believe that pediatric HD now should be regarded as a distinctive EBV-related lymphoma. Cancer 2001;92:1621–31. © 2001 American Cancer Society.
Databáze: OpenAIRE
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