The synthesis of a new active-site analogue of cytochrome P450 carrying substrate recognition sites and athiolate ligand

Autor:	Hamed Aissaoui, Christoph Gmür, Sandro Ghirlanda, Wolf-Dietrich Woggon
Rok vydání:	1996
Předmět:	biology Stereochemistry Ligand Process Chemistry and Technology Active site Cytochrome P450 Substrate recognition Porphyrin Catalysis chemistry.chemical_compound chemistry biology.protein Dimethyl glutarate Physical and Theoretical Chemistry
Zdroj:	Journal of Molecular Catalysis A: Chemical. 113:393-402
ISSN:	1381-1169
DOI:	10.1016/s1381-1169(96)00166-5
Popis:	The synthesis of a new mono-bridged iron(III)porphyrin 2 is described which contains all structural elements significant to an active-site analogue of cytochrome P450: (i) a thiolate ligand coordinating to the iron, and (ii) a substrate-recognition site provided by two substructures derived from Kemp's acid which are positioned perpendicular to the porphyrin plane. 1 H-NMR experiments show that esters like dimethyl glutarate bind with K = 137 M −1 .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ee31f7f3f5f00742138cd2e0df6b2b19 https://doi.org/10.1016/s1381-1169(96)00166-5 Zobrazit plný text záznamu Full Text from ScienceDirect