Prolonged administration of erythropoietin increases erythroid response rate in myelodysplastic syndromes: a phase II trial in 281 patients
| Autor: | Evangelos Terpos, Athina Mougiou, Alexandra Kouraklis, Aria Chatzivassili, Evridiki Michalis, Nicholas Giannakoulas, Eleni Manioudaki, Anna Lazaridou, Vassiliki Bakaloudi, Maria Protopappa, Dimitra Liapi, Elisavet Grouzi, Agapi Parharidou, Argyris Symeonidis, Garoufalia Kokkini, Nikolaos P. Laoutaris, George Vaipoulos, Nikolaos I. Anagnostopoulos, John I. Christakis, John Meletis, Konstantinos L. Bourantas, Nicholas C. Zoumbos, Xenophon Yataganas, Nora-Athina Viniou for The Greek MDS Study Grou |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
business.industry Myelodysplastic syndromes Hematology Ringed Sideroblasts Blast Count medicine.disease Gastroenterology Haematopoiesis Endocrinology Erythropoietin hemic and lymphatic diseases Internal medicine Erythroid response Medicine Erythropoiesis business Refractory anaemia medicine.drug |
| Zdroj: | British Journal of Haematology. 118:174-180 |
| ISSN: | 0007-1048 |
| DOI: | 10.1046/j.1365-2141.2002.03583.x |
| Popis: | Summary. Treatment with recombinant human erythropoietin (rHuEpo) improves anaemia in approximately 20% of patients with myelodysplastic syndromes (MDS). We investigated the potential advantage of a prolonged administration of rHuEpo to achieve higher erythroid response rates (RR) in 281 MDS patients: 118 with refractory anaemia (RA), 77 with refractory anaemia and ringed sideroblasts (RARS), 59 with refractory anaemia with excess of blasts and blast count 150 U/l at baseline predicted for non-response. The median duration of response was 68 weeks and the overall risk of leukaemic transformation was 21·7%. These results suggest that prolonged administration of rHuEpo produces high and long-lasting erythroid RR in MDS patients with low blast counts, particularly in those with pretreatment serum Epo levels of < 150 U/l and good cytogenetic prognosis. |
| Databáze: | OpenAIRE |
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