Additional file 4: of Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association

Autor:	Tonsing-Carter, Eva, Hernandez, Kyle, Kim, Caroline, Harkless, Ryan, Oh, Alyce, Bowie, Kathleen, West-Szymanski, Diana, Betancourt-Ponce, Mayra, Green, Bradley, Lastra, Ricardo, Gini Fleming, Sarat Chandarlapaty, Conzen, Suzanne
Předmět:	3. Good health
Popis:	Figure S2. SGRMs do not effect ER-mediated T47D-Y (GR-negative) cell proliferation or bind to purified ER LBD. A) Steady-state GR, ER-α, and β-actin expression was evaluated in parental T47-D and ER+/GR-negative T47D-Y cells. B) T47D-Y cell proliferation during 8 days vehicle (ETOH, Veh), 10 nM E2, E2/100 nM Dex, E2/1 μM C297, or E2/1 μM C335 treatment. GR liganding (Dex, C297, or C335) does not inhibit E2-mediated proliferation (****p
Databáze:	OpenAIRE
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