Ammonium derivatives of chromenones and quinolinones as lead antimicrobial agents

Autor:	Abha Kathuria, Sunil K. Sharma, Virinder S. Parmar, Shilpi Gupta, Gainda L. Sharma, Bharat Singh, Erik V. Van der Eycken, Sweta Sharma, Seema Singh, Ram Kumar, Manish Kumar, Anjali Gupta
Rok vydání:	2011
Předmět:	Drug Lysis media_common.quotation_subject General Chemistry Antimicrobial In vitro chemistry.chemical_compound chemistry Toxicity Organic chemistry MTT assay Ammonium Cytotoxicity Nuclear chemistry media_common
Zdroj:	Journal of Chemical Sciences. 124:437-449
ISSN:	0973-7103 0974-3626
Popis:	A series of novel ammonium derivatives were synthesized and examined for their antimicrobial efficacy. Comparison of antimicrobial spectrum revealed that compounds 9, 11, 16 and 23 had strong potential against pathogens in vitro. Cytotoxicity results showed compound 9 to be least toxic, it is non-toxic to A549 and U87 cells in MTT assay and exhibits marginal toxicity (15–20%) to human erythrocytes at a concentration of 1000 μg/ml as compared to 100% lysis of cells by 31.25 μg/ml of the standard drug amphotericin B. This compound has MIC values in the range of 1.95–31.25 μg/disc in DDA against different pathogens and may considered to be an important lead antimicrobial molecule for further exploration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ee1b74bd452c7427dc9466415b6c71be https://doi.org/10.1007/s12039-011-0147-7 Zobrazit plný text záznamu Full text from SpringerLink