1,5-Double-Carboxylation of 2-Alkylheteroarenes Mediated by a Combined Brønsted Base System
| Autor: | Yoshinori Kondo, Masanori Shigeno, Itsuki Tohara, Kanako Nozawa-Kumada |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Synlett. |
| ISSN: | 1437-2096 0936-5214 |
| DOI: | 10.1055/a-1990-5360 |
| Popis: | This paper reports that a combined Brønsted base (t-BuOLi/CsF or LiOCEt3/CsF) system mediates the 1,5-double-carboxylation of nonfused 2-alkylhetarenes at both the benzylic and δ-positions. A wide range of functional groups (OMe, F, Cl, CF3, OCF3, sulfide, CN, amide, ketone, or sulfone) are tolerated under the established reaction conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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