Short and simple synthesis of (R)- and (S)-4-hydroxypentylaminoacetamide: both enantiomers of the (ω-1)-hydroxylated metabolite of milacemide

Autor:	Claude Delatour, Jean-Pierre Van Hoeck, Anne M. Mockel, Hugo Gorissen, Guido H. Journée, Valéry R. Libert
Rok vydání:	1992
Předmět:	Pharmacology chemistry.chemical_classification Stereochemistry Milacemide Metabolite Organic Chemistry Reductive amination Catalysis Analytical Chemistry Kinetic resolution Hydroxylation chemistry.chemical_compound chemistry Drug Discovery Enantiomer Enantiomeric excess Spectroscopy Lactone
Zdroj:	Chirality. 4:286-294
ISSN:	0899-0042
DOI:	10.1002/chir.530040505
Popis:	Both (R)- and (S)-4-hydroxypentylaminoacetamide have been synthesized by reductive amination of glycinamide on the γ-valerolactols corresponding to (R)- and (S)-γ-valerolactone, respectively. These enantiomeric lactones were readily obtained in high enantiomeric excess (ee) by enzymic porcine pancreatic lipase (PPL) kinetic resolution of rac-methyl γ-hydroxyvalerate. © 1992 Wiley-Liss, Inc.
Databáze:	OpenAIRE
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