Periostin Plays a Key Role in Radioresistance of Head and Neck Cancer Cells Via Epithelial-to-Mesenchymal Transition
| Autor: | Somi Ryu, Jung Je Park, Ji Hyun Seo, Jin Pyeong Kim, Hyo Won Chang, Jong Sil Lee, Seong Jun Won, Jeong Seok Hwa, Hee Young Cho, So Young Cheon, Sang Yoon Kim, Young-Sool Hah |
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| Rok vydání: | 2020 |
| Předmět: |
MAPK/ERK pathway
Cancer Research business.industry Mesenchymal stem cell General Medicine Periostin medicine.disease Head and neck squamous-cell carcinoma stomatognathic diseases 03 medical and health sciences 0302 clinical medicine stomatognathic system Oncology 030220 oncology & carcinogenesis Radioresistance Cancer research Medicine Gene silencing Epithelial–mesenchymal transition business Protein kinase B |
| Zdroj: | Anticancer Research. 40:2627-2635 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.14233 |
| Popis: | Background/aim Head and neck squamous cell carcinoma (HNSCC) is an aggressive head and neck malignancy. The aim of this study was to elucidate the role of periostin (POSTN) in the epithelial-to-mesenchymal transition (EMT) process mediating the acquisition of radioresistance in HNSCC. Materials and methods The expression levels of EMT hallmark genes including POSTN and Erk/Akt signaling pathways were compared between radiosensitive and radioresistant HNSCC cells. Results POSTN mRNA expression was higher in radioresistant HNSCC cells, and silencing POSTN significantly impaired their invasiveness under the effect of EMT process represented by up-regulation of mesenchymal markers and down-regulation of an epithelial marker. Expression levels of Erk and Akt were higher in radioresistant cells. Conclusion POSTN in association with the Erk and Akt signaling pathways was up-regulated during the EMT process, leading to the conversion of radiosensitive to radioresistant HNSCC cells. POSTN may be a key marker for predicting the radioresistance and therapeutic target of HNSCC. |
| Databáze: | OpenAIRE |
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