Salvia connivens, a Source of Bioactive Flavones with Amoebicidal and Giardicidal Activity
| Autor: | Mabel Fragoso-Serrano, Daphne E. González-Juárez, Lilián Yépez-Mulia, Guillermo Pastor-Palacios, Brenda Y. Bedolla-García, Fernando Calzada, Elihú Bautista |
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| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Traditional medicine 010405 organic chemistry medicine.drug_class Biology Salvia biology.organism_classification medicine.disease_cause 01 natural sciences Flavones 0104 chemical sciences 010404 medicinal & biomolecular chemistry Entamoeba histolytica chemistry Phytochemical parasitic diseases medicine Antiprotozoal Giardia lamblia Lamiaceae General Pharmacology Toxicology and Pharmaceutics Medicinal plants |
| Zdroj: | Revista Brasileira de Farmacognosia. 30:729-732 |
| ISSN: | 1981-528X |
| Popis: | Salvia connivens Epling, Lamiaceae, is an annual herbaceous plant used as a traditional medicine in Mexico for the treatment of diarrhea, which out can be caused by bacterial, viral, and protozoal infections, as well as toxins mainly. Mexican medicinal plants with anti-diarrheic activity represent a source of potential antiprotozoal agents. The phytochemical isolation of the constituents of an acetone-soluble extract led to the isolation of the known flavonoids: eupatorin, cirsiliol, and nuchensin. The structures of these compounds were elucidated by the analysis of their NMR and MS data. Nuchensin displayed potent antiprotozoal activity against Entamoeba histolytica (IC50 0.072 ± 0.006 μM) and Giardia lamblia (IC50 0.118 ± 0.006 μM), which was comparable to metronidazole. |
| Databáze: | OpenAIRE |
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