Regulation of glucose transport in skeletal muscle 1

Autor:	J F Youngren, R J Barnard
Rok vydání:	1992
Předmět:	biology business.industry Insulin medicine.medical_treatment Glucose transporter Membrane transport medicine.disease Biochemistry Transport protein Insulin receptor Insulin resistance Genetics medicine biology.protein Phosphorylation business Molecular Biology Tyrosine kinase Biotechnology
Zdroj:	The FASEB Journal. 6:3238-3244
ISSN:	1530-6860 0892-6638
DOI:	10.1096/fasebj.6.14.1426762
Popis:	The entry of glucose into muscle cells is achieved primarily via a carrier-mediated system consisting of protein transport molecules. GLUT-1 transporter isoform is normally found in the sarcolemmal (SL) membrane and is thought to be involved in glucose transport under basal conditions. With insulin stimulation, glucose transport is accelerated by translocating GLUT-4 transporters from an intracellular pool out to the T-tubule and SL membranes. Activation of transporters to increase the turnover number may also be involved, but the evidence is far from conclusive. When insulin binds to its receptor, it autophosphorylates tyrosine and serine residues on the beta-subunit of the receptor. The tyrosine residues are thought to activate tyrosine kinases, which in turn phosphorylate/activate as yet unknown second messengers. Insulin receptor antibodies, however, have been reported to increase glucose transport without increasing kinase activity. Insulin resistance in skeletal muscle is a major characteristic of o...
Databáze:	OpenAIRE
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