Lipophilic bis-arylsulfonates as inhibitors of the CD4-gp120 interaction

Autor:	Azis Kongsjahju, Marie-Rose van Schravendijk, Ariamala Gopalsamy, Kristin A. Gordon, Kevin Daniels, Raymond J. Patch, Huai Gao, Paul J. Kowalczyk, Peter V. Pallai, Zhan Shi, John C. Roberts
Rok vydání:	1996
Předmět:	Inhibitory potency Chemistry Organic Chemistry Clinical Biochemistry Drug Discovery Lipophilicity Pharmaceutical Science Molecular Medicine Organic chemistry Molecular Biology Biochemistry Arylsulfonates
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 6:2983-2988
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(96)00552-5
Popis:	A series of lipophilic bis-arylsulfonates was synthesized and evaluated as potential inhibitors of the CD4-gp120 interaction. Structure-activity studies suggested a direct relationship between the nature and extent of lipophilicity and inhibitory potency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::edf3169fcc89251c399d7ebc10f53a51 https://doi.org/10.1016/s0960-894x(96)00552-5 Zobrazit plný text záznamu Full Text from ScienceDirect