Contaminated polio vaccine theory refuted

Autor:	Paul M. Sharp, Beatrice H. Hahn, Jean Bosco N. Ndjango, Bernard L. Labama, Michael Worobey, George M. Shaw, Benoît D. Dhed'a, Jeffrey B. Joy, Brandon F. Keele, Andrew Rambaut, Mario L. Santiago
Rok vydání:	2004
Předmět:	Multidisciplinary Human immunodeficiency virus (HIV) Oral polio vaccine Simian immunodeficiency virus Biology medicine.disease medicine.disease_cause Virology Virus Polio vaccine Acquired immunodeficiency syndrome (AIDS) Immunology medicine Aids pandemic
Zdroj:	Nature. 428:820-820
ISSN:	1476-4687 0028-0836
DOI:	10.1038/428820a
Popis:	Despite strong evidence to the contrary, speculation continues that the AIDS virus, human immunodeficiency virus type 1 (HIV-1), may have crossed into humans as a result of contamination of the oral polio vaccine (OPV). This 'OPV/AIDS theory' claims that chimpanzees from the vicinity of Stanleyville--now Kisangani in the Democratic Republic of Congo--were the source of a simian immunodeficiency virus (SIVcpz) that was transmitted to humans when chimpanzee tissues were allegedly used in the preparation of OPV. Here we show that SIVcpz is indeed endemic in wild chimpanzees of this region but that the circulating virus is phylogenetically distinct from all strains of HIV-1, providing direct evidence that these chimpanzees were not the source of the human AIDS pandemic.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::edf28850fc28236b9042c8dbac5a081f https://doi.org/10.1038/428820a Zobrazit plný text záznamu Plný text ve formátu PDF