Synthesis and EPR Evaluation of the Nitrone PBN-[tert-13C] for Spin Trapping Competition

Autor:	Yong-Kang Zhang, Kirk R. Maples
Rok vydání:	2002
Předmět:	chemistry.chemical_classification Spin trapping Radical General Chemistry Photochemistry Medicinal chemistry law.invention Nitrone Adduct chemistry.chemical_compound Epr spin trapping chemistry law Hydroxyl radical Electron paramagnetic resonance
Zdroj:	Zeitschrift für Naturforschung B. 57:127-132
ISSN:	1865-7117 0932-0776
DOI:	10.1515/znb-2002-0116
Popis:	N-[tert-13C]Butyl C-phenyl nitrone (PBN-[tert-13C]) has been synthesized for an EPR spin trapping competition study. The newly synthesized PBN-[tert-13C] shows different 13C-hyperfine splitting constants (a13C) when it traps free radicals as compared to another 13C-labeled PBN analogue, N-tert-butyl C-phenyl [nitronyl-13C]nitrone (PBN-[nitronyl-13C]). The PBN- [tert-13C] hydroxyl adduct gives a larger a13C value (5.14 G) as compared to the PBN-[nitronyl-13C] hydroxyl adduct (4.36 G). This gain ofthe a13C value decreases the chance of EPR signal overlap, thus providing a more resolved EPR spectrum when PBN-[tert-13C] is used as an internal standard for EPR spin trapping competition studies of hydroxyl radical formation.
Databáze:	OpenAIRE
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