SNAr Reactions of 2-haloarylsulfoxides with alkoxides provide a novel synthesis of thiotomoxetine

Autor:	Andrew Michael Ratz, Leland Otto Weigel
Rok vydání:	1999
Předmět:	chemistry.chemical_compound chemistry Nucleophilic aromatic substitution Stereochemistry Aryl Organic Chemistry Drug Discovery Moiety Selective reduction Alcohol Ether Biochemistry Combinatorial chemistry
Zdroj:	Tetrahedron Letters. 40:2239-2242
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(99)00215-4
Popis:	A five step synthesis of thiotomoxetine ( 2 ) is described. Installation of the aryl ether was accomplished using a highly efficient S N Ar fragment coupling between amino alcohol ( 4 ) and a 1-halo-2-methylsulfinylbenzene (X = F or Cl) followed by a selective reduction of the arylsulfoxide moiety.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::edea01d2baa6ee398e9340ee5a6c65ac https://doi.org/10.1016/s0040-4039(99)00215-4 Zobrazit plný text záznamu Full Text from ScienceDirect