Genomic epidemiology of nontoxigenic Corynebacterium diphtheriae from King County, Washington State, USA between July 2018 and May 2019
| Autor: | Lingzi Xiaoli, Shelly McKeirnan, Meagan Kay, Eileen Benoliel, Chas DeBolt, Vance Kawakami, Jeffery Duchin, Yanhui Peng, Scott Lindquist, Maria Lucia Tondella, Anna M. Acosta, Janessa S. Aneke, Michael R. Weigand, Pamela K. Cassiday |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Corynebacterium diphtheriae Genetics medicine.medical_specialty biology Genomic data Biovar 030106 microbiology Outbreak Single-nucleotide polymorphism General Medicine biology.organism_classification Disease cluster Genome 03 medical and health sciences 030104 developmental biology Epidemiology medicine |
| Zdroj: | Microbial Genomics. 6 |
| ISSN: | 2057-5858 |
| Popis: | Between July 2018 and May 2019, Corynebacterium diphtheriae was isolated from eight patients with non-respiratory infections, seven of whom experienced homelessness and had stayed at shelters in King County, WA, USA. All isolates were microbiologically identified as nontoxigenic C. diphtheriae biovar mitis. Whole-genome sequencing confirmed that all case isolates were genetically related, associated with sequence type 445 and differing by fewer than 24 single-nucleotide polymorphisms (SNPs). Compared to publicly available C. diphtheriae genomic data, these WA isolates formed a discrete cluster with SNP variation consistent with previously reported outbreaks. Virulence-related gene content variation within the highly related WA cluster isolates was also observed. These results indicated that genome characterization can readily support epidemiology of nontoxigenic C. diphtheriae . |
| Databáze: | OpenAIRE |
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