ChemInform Abstract: Pyrimido(1,6-a)benzimidazoles: A New Class of DNA Gyrase Inhibitors

Autor:	Hans Gmuender, Peter Angehrn, Christian Hubschwerlen, Philippe Pflieger, Klaus Gubernator, Jean-Luc Specklin, Ivan Kompis
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Enzyme chemistry Stereochemistry Protein subunit Biological activity General Medicine DNA Gyrase Inhibitors DNA gyrase
Zdroj:	ChemInform. 24
ISSN:	0931-7597
DOI:	10.1002/chin.199301207
Popis:	Substituted 4-quinolone- (1, A = CH) and 1,8-naphthyrid-4-one- (1, A = N) 3-carboxylic acids are currently the only classes of clinically useful antibacterial agents exerting their activity by inhibiting the subunit A of DNA gyrase. Pyrimido[1,6-alpha]benzimidazoles 11 have been found to be a new class of inhibitors of this enzyme. The design, synthesis, and biological activity of these compounds are reported.
Databáze:	OpenAIRE
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