A Case of Leukocyte Adhesion Deficiency (LAD) Presenting with Nasal Septum Perforation and Necrotizing Ulcer on Ala Nasi

Autor:	Ilhan Tezcan, Fügen Ersoy, A. Izzet Berkel, Metin Önerci, Leman Yel, Ozden Sanal
Rok vydání:	1996
Předmět:	medicine.medical_specialty Pathology Nasal septum perforation Otorhinolaryngology business.industry Medicine business medicine.disease Surgery Leukocyte adhesion deficiency
Zdroj:	American Journal of Rhinology. 10:383-386
ISSN:	1539-6290 1050-6586
Popis:	We report on a 3 month-old female patient having leukocyte adhesion deficiency (LAD) of severe phenotype presenting with perforation of the nasal septum and ulceration on the right ala nasi. Laboratory investigations revealed marked leukocytosis, defective neutrophil adherence to glass beads and chemotaxis, decreased NK cell cytotoxicity, and undetectable expression of CD18 on lymphocytes. We conclude that the possibility of this entity should be kept in mind in the presence of such a necrotic lesion in early childhood.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::edd31a10a7d7c3460ffe46094ce66e49 https://doi.org/10.2500/105065896781794806 Zobrazit plný text záznamu