A study of occurrence of non-alcoholic steatohepatitis in children with obesity and overweight
| Autor: | Meghana Somasundara, Sharanagouda Patil, Kumar Angadi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Fatty liver nutritional and metabolic diseases Overweight medicine.disease digestive system Gastroenterology digestive system diseases Insulin resistance Internal medicine medicine Homeostatic model assessment Steatohepatitis Metabolic syndrome medicine.symptom Liver function tests business Body mass index |
| Zdroj: | Indian Journal of Child Health. 8:314-318 |
| ISSN: | 2349-6126 2349-6118 |
| DOI: | 10.32677/ijch.v8i9.3018 |
| Popis: | Background: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and its increasingprevalence is associated with a concomitant rise in obesity. Anthropometric measurements and non-invasive tests (liver function tests and USG abdomen) help in early recognition of non-alcoholic steatohepatitis (NASH) and reduce consequent morbidity and mortality. Aim: This study aims to study the occurrence of NASH in obese and overweight children and to derive the correlation of NASH with clinical and biochemical parameters in overweight and obese children. Methods: This hospital-based prospective study included children (age?18 years) who met the inclusion criteria. Diagnosis of NASH was based on the USG abdomen. Measurements included anthropometry, ultrasonography, fasting glucose, alanine aminotransferase (ALT), lipid profile and additional parameters of blood pressure, fasting insulin, and homeostatic model assessment of insulin resistance (HOMA-IR). The variables were compared between children with and without NASH. Results: A total of 146 patients (female: 51.4%, male: 48.6%) were enrolled in the study. The most common age group affected was 11–18 years (50.7%) followed by 6–10 years (43.2%) and |
| Databáze: | OpenAIRE |
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