Productive plasmapheresis by Nigale NGL XJC 2000: quality controls on plasma collected

Autor: M. Cirella, F. Annarumma, G. Vaccaro, L. Paesano, R. Pecora, M. D’Onofrio, C. Nocera, S. Misso
Rok vydání: 2014
Předmět:
Zdroj: Transfusion and Apheresis Science. 50:S13-S14
ISSN: 1473-0502
DOI: 10.1016/s1473-0502(14)50029-8
Popis: Methods: We report a case study of a patient, 26 year old, with severe hemophilia A. The patient, a physical education’s university student, because hemophilic arthropathy of the right ankle, had difficulty to carry out the physical activity required by his course of study, despite being a prophylaxis regimen. MRI (magnetic resonance imaging) of the ankle showed the following: Outbreak chondromalacia (grade II/III) borne by tibial limiting of tibial–astragalus joint and the talar dome on the medial side; similar but smaller entities’ framework borne by the calcaneal articular surface of the talocalcaneal joint. Fair inflammatory thickening of the tibial–talar sinovial tissue. Deformed appearance of the talar dome. Tenosynovitis of tibialis anterior tendon. We used a therapeutic protocol consisting of a cycle of three infiltrations of PRG at weekly intervals (7/10 days), for a total of about 12ml (about 4ml per infusion). The intraarticular infiltration, ultrasonography-guided, is conducted, after intravenous infusion of recombinant FVIII concentrate, following careful disinfection of the skin, with the patient in the supine position and the ankle to be treated flexed in neutral position. Results: After three infusions the patient obtained a clear decrease in pain and an improvement in joint function. There was a significant reduction in articular Pettersson Score which passed from 7 to 3. Conclusions: Our work is a pilot study on the use of PRG in joints affected by hemophilic arthropathy; the preliminary data provide an excellent starting point for further development of the technique with possible applications also in other anatomical districts.
Databáze: OpenAIRE
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