Association between bronchopulmonary dysplasia and MBL2 and IL1-RN polymorphisms
| Autor: | Şebnem Çalkavur, Bilin Cakmak, Emin Karaca, Mete Akisu, Mehmet Yalaz, Nilgün Kültürsay, Ferda Ozkinay, Ozge Altun Koroglu, Gulcin Itirli, Hüseyin Onay |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Neonatal sepsis business.industry Odds ratio medicine.disease Gastroenterology Neonatal infection Bronchopulmonary dysplasia Internal medicine mental disorders Pediatrics Perinatology and Child Health Immunology Genotype Genetic predisposition medicine Gestation Gene polymorphism business |
| Zdroj: | Pediatrics International. 54:863-868 |
| ISSN: | 1328-8067 |
| DOI: | 10.1111/j.1442-200x.2012.03714.x |
| Popis: | Background The imbalance between pro-inflammatory and anti-inflammatory cytokines may play a role in the development of bronchopulmonary dysplasia (BPD) in preterm infants. Mannose binding lectin (MBL) codon 54 and interleukin 1 receptor antagonist gene (IL1-RN) polymorphisms cause genetic predisposition to increased risk of infection and inflammation, therefore may increase the risk of BPD. The aim of this study was to investigate the relationship between MBL, IL1-RN gene polymorphisms and BPD development in preterm infants. Methods MBL codon 54 and IL1-RN polymorphisms were studied in 71 infants who were born at |
| Databáze: | OpenAIRE |
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