Opioid Modulation of Social Bonds in Humans
| Autor: | Trøstheim, Martin, Eikemo, Marie, Løseth, Guro, Leknes, Siri |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Neuroscience and Neurobiology
Social connectedness Double-blind Randomized Life Sciences Opioid blockade Social and Behavioral Sciences Naltrexone Chemicals and Drugs FOS: Psychology Opioids Meta-analysis Opioid antagonist Medicine and Health Sciences Systematic review Psychology Social bonding Endorphins Healthy controls Endogenous opioids Placebo Human |
| DOI: | 10.17605/osf.io/x5wmq |
| Popis: | Panksepp’s Brain Opioid Theory of Social Attachment (Panksepp et al., 1978) proposed that that endogenous opioids promote the formation and maintenance of social bonds across species by mediating feelings of pleasure and security experienced in the presence of others. A literature synthesis from our group later suggested that opioids promote approach in safe contexts, whilst mainly providing relief when the animal is in distress (Løseth et al., 2014). Here, we conduct a systematic review and meta-analysis of opioid modulation of social bonds in healthy humans. Some recent human studies have used opioid antagonists to probe mu-opioid dependent social processes. For instance, Inagaki et al. (2015) gave naltrexone to participants over four days and found a significant increase in diary ratings of feeling ‘disconnected from others’ compared to placebo. An acute naltrexone dose yielded a similar finding in Inagaki et al. (2020) but no effect in Tarr et al. (2017). Tchalova and MacDonald (2020) reported that participants pretreated with naltrexone both disclosed less in a self-disclosure task, and also failed to display a task-related mood improvement evident in the placebo group. We consider the evidence of opioid modulation of social bonding or connectedness in healthy humans in relation to findings from 1) non-human animals, and 2) non-social reward in humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|