Cephalosporin Tin(II) Complexes: Synthesis, Characterization, and Antibacterial Activity

Autor:	J. R. Anacona, Liangel Brito, Wenceslao Peña
Rok vydání:	2012
Předmět:	Denticity Ligand Chemistry chemistry.chemical_element equipment and supplies Medicinal chemistry Inorganic Chemistry chemistry.chemical_compound Amide polycyclic compounds Lactam Organic chemistry Carboxylate Physical and Theoretical Chemistry Cephradine Tin Antibacterial activity
Zdroj:	Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry. 42:1278-1284
ISSN:	1553-3182 1553-3174
DOI:	10.1080/15533174.2012.680164
Popis:	The synthesis and spectral characterization of mononuclear cephalosporin tin(II) complexes of general formula [Sn(L)Cl] (L = monoanion of cephalothin HL1, cephradine HL2, cefotaxime HL3, cefazolin HL4, and ceftriaxone HL5), are reported. They were characterized by physicochemical and spectroscopic methods. The spectra indicated that the antibiotics act as multidentate ligand toward metal ions, via the amide and lactam carbonyl and carboxylate and N-azomoieties. The complexes are nontoxic, insoluble in water, and common organic solvents and probably have polymeric structures. The ligands and their tin complexes have been screened for their antibacterial activities and found to be quite active in this respect. Coordination of cephalothin and cephradine to tin(II) ion showed an enhancement of the antibacterial activity.
Databáze:	OpenAIRE
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