Two Mixed-Ligand Co(II)-Based Coordination Polymers: Application Value in the Later Rehabilitation of Fracture Patients by Activating WNT Signaling Pathway
| Autor: | Chuan-Hao Bi, Zheng-Hua Kan, Yu-Jun Qi, Juan Shen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Stereochemistry Mesenchymal stem cell Wnt signaling pathway 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Fibroblast growth factor 01 natural sciences Biochemistry 0104 chemical sciences Vascular endothelial growth factor Blot chemistry.chemical_compound Enzyme chemistry Imidazole General Materials Science Signal transduction 0210 nano-technology |
| Zdroj: | Journal of Cluster Science. 33:37-43 |
| ISSN: | 1572-8862 1040-7278 |
| Popis: | Two coordination polymers containing Co(II) ions as the metal source have been prepared by the hydrothermal reaction, and their chemical formulae are {[Co(Hnbta)(bimm)](3H2O)}n (1) and {[Co1.5(nbta)(pyim)(H2O)](2H2O)}n (2) (pyim = N-(4-pyridylmethyl)imidazole, bimm = bis(imidazol-1-yl)methane and H3nbta = 5-nitro-1,2,3-benzenetricarboxylic acid) and. The application values of the new compound in the later rehabilitation of fracture patients were assessed and the detailed mechanism was investigated as well. First of all, the Vascular endothelial growth factor (VEGF) content and Fibroblast growth factor (FGF) content was evaluated with enzyme linked immunosorbent assay (ELISA) detection kit, and the results indicated compound 1 was much stronger than compound 2 on increasing the VEGF and FGF content. In addition to this, the activation levels of the Wingless-type (Wnt) signaling pathway in mesenchymal stem cells was followed by western blotting assay, the data suggested that compound 1 could up-regulated the activation levels of the Wnt signaling pathway. |
| Databáze: | OpenAIRE |
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