Cytotoxicity of plant flavonoids against HeLa cells
| Autor: | Nobuyasu Enoki, Chikao Nishino, Akihisa Mori, Shinkichi Tawata |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
chemistry.chemical_classification
biology Flavonoid food and beverages Plant Science General Medicine Horticulture biology.organism_classification Biochemistry Flavones Uridine HeLa chemistry.chemical_compound chemistry Structure–activity relationship Myricetin Thymidine Cytotoxicity Molecular Biology |
| Zdroj: | Phytochemistry. 27:1017-1020 |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/0031-9422(88)80264-4 |
| Popis: | (-)-Epigallocatechin and 28 other plant flavonoids were tested for cytotoxic activity against HeLa cells. Flavones and flavanones were active and several compounds with planar and non-planar ring systems showed high cytotoxic activities. Although no clear structure activity relationship was deduced, hydroxyl groups on the A- and B- ring affected the cytotoxic potency positively or negatively, depending on the position of substitution. The uptake of thymidine was predominantly inhibited by myricetin, whereas the uptake of uridine was inhibited by (−)- epigallocatechin; the uptake of both thymidine and uridine were inhibited by 7,8-dihydroxyflavone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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