Development of a murine model resembling human lupus in mice parasitized with Trichinella spiralis
| Autor: | Christian Irene Nevárez-Lechuga, Sandra Sánchez-Barbosa, Carla Landa-Saldívar, Carlos Wong, Carlos Wong-Baeza, Alejandro Escobar-Gutiérrez, Jorge-Luis de-la-Rosa-Arana, Isabel Baeza |
|---|---|
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 200:175.16-175.16 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.200.supp.175.16 |
| Popis: | Deregulation of Th1 and Th17 immune responses is fundamental in the development of autoimmune diseases, like Systemic Lupus Erythematosus that is a chronic inflammatory autoimmune disease characterized by the production of autoantibodies that cause inflammation and damage to different organs. New therapeutic approaches for autoimmune diseases have been based on the fact that nematodes such as Trichinella spiralis decrease the inflammatory response by inducing the production of anti-inflammatory cytokines, which are potent modulators of T cell function. Recent studies have shown that the proteins secreted by T. spiralis, or the infection itself, induce a polarized Th2/Treg response and the production of regulatory cytokines, which are associated with the amelioration of autoimmune diseases such as colitis, respiratory tract inflammation, type 1 diabetes and experimental autoimmune encephalomyelitis. In this work, mice were infected and, after the life cycle was completed, a procedure to develop lupus was performed. The level of autoantibodies and antibodies anti-Trichinella were detected as well as the levels of Th1 and Th2 cytokines. Here, we show the relevance of studying the immune response in a murine model resembling the human lupus in the presence of T. spiralis muscular larvae, because it provides new information on the immunoregulation of lupus and reveals the effect on its progression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|