Interferon Regulatory Factor-9 (IRF-9) Mediates Short Term Host Protection, but Promotes Long Term Immune Injury in Evolution of Myocarditis Leading to Dilated Cardiomyopathy

Autor:	Eleanor N. Fish, Yu Shi, Manyin Chen, Michael Konviser, Anne Opavsky, Peter Liu, Youan Liu, Anthony O. Gramolini, Mei Sun
Rok vydání:	2007
Předmět:	Innate immune system Viral Myocarditis Myocarditis business.industry Inflammation medicine.disease Acquired immune system Immune system Interferon Immunology medicine medicine.symptom Cardiology and Cardiovascular Medicine business Interferon regulatory factors medicine.drug
Zdroj:	Journal of Cardiac Failure. 13:S101
ISSN:	1071-9164
Popis:	Evolution of viral myocarditis to dilated cardiomyopathy (DCM)represents a delicate balance between host innate immunity and T-cell acquired immunity. IRF-9 is a key member of a transcription factor family that regulates type I interferon (IFN) production, critical for innate antiviral protection. RESULTS: IRF9-/- mice showed dramatically increased mortality compared to the wildtype littermates (0% WT vs 72% IRF-9-/- on day 14, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eda3480a5a4fcca9c72af699dae4b07c https://doi.org/10.1016/j.cardfail.2007.06.402 Zobrazit plný text záznamu Full Text from ScienceDirect