Autor: |
Eleanor N. Fish, Yu Shi, Manyin Chen, Michael Konviser, Anne Opavsky, Peter Liu, Youan Liu, Anthony O. Gramolini, Mei Sun |
Rok vydání: |
2007 |
Předmět: |
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Zdroj: |
Journal of Cardiac Failure. 13:S101 |
ISSN: |
1071-9164 |
Popis: |
Evolution of viral myocarditis to dilated cardiomyopathy (DCM)represents a delicate balance between host innate immunity and T-cell acquired immunity. IRF-9 is a key member of a transcription factor family that regulates type I interferon (IFN) production, critical for innate antiviral protection. RESULTS: IRF9-/- mice showed dramatically increased mortality compared to the wildtype littermates (0% WT vs 72% IRF-9-/- on day 14, P |
Databáze: |
OpenAIRE |
Externí odkaz: |
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