Clinical Factors Associated with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections
| Autor: | Adam B. Lewin, Paula J. Edge, Tanya K. Murphy, Wayne K. Goodman, Eric A. Storch |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pediatrics
medicine.medical_specialty Tics medicine.diagnostic_test business.industry Pediatric acute-onset neuropsychiatric syndrome Medical record Physical examination medicine.disease medicine.disease_cause PANDAS Pediatrics Perinatology and Child Health Streptococcus pyogenes Group A streptococcal infection Medicine Family history business Psychiatry |
| Zdroj: | The Journal of Pediatrics. 160:314-319 |
| ISSN: | 0022-3476 |
| Popis: | Objective To explore associated clinical factors in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). Study design Children with tics, obsessive-compulsive disorder, or both (n = 109) were examined with personal and family history, diagnostic interview, physical examination, medical record review, and measurement of baseline levels of streptococcal antibodies. Results Significant group differences were found on several variables, such that children in whom PANDAS (versus without PANDAS) were more likely to have had dramatic onset, definite remissions, remission of neuropsychiatric symptoms during antibiotic therapy, a history of tonsillectomies/adenoidectomies, evidence of group A streptococcal infection, and clumsiness. Conclusion The identification of clinical features associated with PANDAS should assist in delineating risks for this subtype of obsessive-compulsive disorder/tics. |
| Databáze: | OpenAIRE |
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