Pilot prospective study of Frailty and Functionality in routine clinical assessment in allogeneic hematopoietic cell transplantation

Autor: Maria Queralt Salas, Arjun Datt Law, Eshetu G. Atenafu, Jeffrey H. Lipton, Ivan Pasic, Wilson Lam, Ora Bascom, Zeyad Al-Shaibani, Dennis Dong Hwan Kim, Jonas Mattsson, Leeann Wilson, Fotios V. Michelis, Armin Gerbitz, Rajat Kumar, Auro Viswabandya, Shabbir M.H. Alibhai
Rok vydání: 2020
Předmět:
Zdroj: Bone Marrow Transplantation. 56:60-69
ISSN: 1476-5365
0268-3369
Popis: A Frailty and Functionality evaluation for alloHCT was implemented using existing resources. We describe the implementation of this evaluation across all ages and at first consultation, and correlate results with posttransplant outcomes in 168 patients. The evaluation consists of: Clinical Frailty Scale (CFS), Instrumental Activities of Daily Living (IADL), grip strength (GS), timed up and go test (TUGT), self-rated health question (SRH), Single question of Falls, albumin and C-Reactive Protein (CRP) levels. Median time to perform the evaluation was 5–6 min. Median age was 58 years (range: 19–77) and median follow-up was 5.3 months. TUGT > 10 s (HR 2.92; p = 0.003), raised CRP (HR 4.40; p 10 s (HR 3.47; p = 0.003), GS (HR 2.56; p = 0.029), SRH ( 10 s and raised CRP were significant predictors for worse OS and NRM. SRH (
Databáze: OpenAIRE
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