Trends regarding viral barrier implementation in animal cell culture processes

Autor:	Matthew S. Croughan, Sean Delfosse, Nathan Hsu, Michelle LaFond, Melissa Sathavipat
Rok vydání:	2013
Předmět:	Upstream (petroleum industry) Mouse minute virus White paper Process management Biopharmaceutical business.industry Cell culture Best practice Biology business Biotechnology
Zdroj:	Pharmaceutical Bioprocessing. 1:351-360
ISSN:	2048-9153 2048-9145
Popis:	Over the past 20 years, a handful of large-scale viral contaminations have been reported along with various strategies, technologies and best practices for mitigation of adventitious viral and mycoplasma contaminations in upstream cell culture processes. Despite the available information, many uncertainties exist regarding implementation of viral barriers for upstream processes. Focusing primarily on high-temperature, short-time treatment of cell culture medium, this White Paper describes the current state of implementation of in-process, upstream viral barriers. It includes blinded data and insights from 12 leading biopharmaceutical companies, as well as six industry-leading consultants. Among 12 companies included in the study, a total of 24 high-temperature, short-time units are currently, or will soon be, in operation. The results generated are beneficial as a guide for viral risk-mitigation efforts, at both established and start-up biopharmaceutical companies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ed98e787a5477c74db86a988343a4877 https://doi.org/10.4155/pbp.13.41 Zobrazit plný text záznamu