Chemical composition and biological activity of total bufadienolides from the Central-Asian Bufo viridis toad venom

Autor:	A. B. Soliev, Sh. I. Salikhov, N. I. Zakirova, A. Yu. Abramov, Z. A. Khushbaktova, M. S. Tashmukhamedov, I. V. Usanova, Vladimir Nikolaevich Syrov, F. G. Kamaev, Sh. Ya. Mirzaakhmedov
Rok vydání:	2007
Předmět:	Pharmacology Chromatography biology Stereochemistry Bufalin Biological activity Venom Toad Nuclear magnetic resonance spectroscopy High-performance liquid chromatography Arenobufagin chemistry.chemical_compound chemistry biology.animal Drug Discovery Chemical composition
Zdroj:	Pharmaceutical Chemistry Journal. 41:600-604
ISSN:	1573-9031 0091-150X
Popis:	The chemical composition of bufadienolides isolated from the venom of Bufo viridis green toad occurring in Central Asia was determined and their biological properties were studied. Six individual bufadienolides were isolated by reverse-phase chromatography on a Lichrosorb RP-8 (10 µ) column in amounts sufficient for qualitative analysis. Two of these were previously identified as arenobufagin and gamabufotalin by NMR spectroscopy and x-ray diffraction methods. The chemical structures of four other bufadienolides are now established by NMR spectroscopy and HPLC. These compounds have been identified as telocinobufagin (3β,5β,14β-trihydroxybufa-20,22-dienolide), marinobufagin (3β, 5β-hydroxy-14,15β-epoxybufa-20,22-dienolide), bufarenogin (3β,12β,14β-hydroxybufa-20,22-dienolide), and bufalin (3β,14β-hydroxybufa-20,22-dienolide).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ed885a26c808ebb058838224fa991f5f https://doi.org/10.1007/s11094-008-0024-y Zobrazit plný text záznamu Plný text ve formátu PDF