AB0163 SERUM LEVELS OF CHEMERIN IN PATIENTS WITH RHEUMATOID ARTHRITIS
| Autor: | Y. Akhverdyan, В. Zavodovsky, E. Papichev, J. Polyakova, L. Seewordova |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Annals of the Rheumatic Diseases. 81:1211.2-1212 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2022-eular.1348 |
| Popis: | BackgroundChemerin (Ch) is one of the relatively new representatives of adipokines. Numerous studies have shown that adipokines are actively involved in inflammation and immune responses in rheumatoid arthritis (RA) [1]. Data have been obtained, on the basis of which it can be assumed that an increase in the level of Ch in the blood serum in patients with certain systemic diseases is associated with systemic inflammation [2, 3].ObjectivesThe aim of the work was to study the level of chemerin in blood serum in a group of healthy donors and patients with RA.MethodsThe group of patients included 92 patients diagnosed with RA, corresponding to the diagnostic criteria developed by ACR and EULAR (2010). The age of the surveyed ranged from 18 to 75 years. The average duration of the disease was 11 years [(Me) [3(25%);16(75%)]. The control group consisted of 30 practically healthy persons aged 26 to 62 years. The group of patients with RA and the control group were comparable in age (p=0.089) and gender (p=0.121). Serum chemerin levels were determined using the commercial HUMAN CHEMERIN ELISA kit (BioVendor, Cat. No.: RD191136200R) according to the instructions provided.ResultsThe level of the normal Ch value in healthy individuals ranged from 134.7 µg/ml to 241.6 ng/ml. The average Ch level in RA patients (calculated as M±2σ) was 462.6±159.82 ng/ml, which is significantly higher than in healthy donors — 169.9±43.47 ng/ml (t=-10.49; p0.2). We also found a moderate correlation between the Ch level and the age of patients with RA (r=0.232008, pConclusionThus, the level of Ch in the blood serum of patients with RA is significantly higher than in healthy individuals. It can be assumed that Ch in RA patients can be used as one of the potential markers of inflammation activity.References[1]Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006;6:772–83.[2]Arita M, Yoshida M, Hong S et al. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci USA 2005; (102):7671–7676.[3]Campbell EL, Louis NA, Tomassetti SE et al. Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution. FASEB J 2007; (21):3162–3170.Disclosure of InterestsNone declared |
| Databáze: | OpenAIRE |
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