Longevity, tumor, and physical vitality in rats consuming ginsenoside Rg1
| Autor: | Chiung-Yun Chang, Chao-Chieh Hsieh, Suchada Saovieng, Chih Yang Huang, Chia-Hua Kuo, Maijian Zhu, Yu-Wen Hsieh, Tania Xu Yar Lee, Jinfu Wu |
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| Rok vydání: | 2023 |
| Předmět: |
0301 basic medicine
business.industry Insulin medicine.medical_treatment media_common.quotation_subject Longevity Physiology Inflammation Vitality Biochemistry Genetics and Molecular Biology (miscellaneous) Locomotor activity Ginsenoside Rg1 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Complementary and alternative medicine Natural death 030220 oncology & carcinogenesis Medicine Tumor necrosis factor alpha medicine.symptom business Biotechnology media_common |
| Zdroj: | Journal of Ginseng Research. 47:210-217 |
| ISSN: | 1226-8453 |
| Popis: | Background Effects of the major ginsenoside Rg1 on mammalian longevity and physical vitality are rarely reported. Purpose To examine longevity, tumor, and spontaneous locomotor activity in rats consuming Rg1. Methods A total of 138 Wistar rats were randomized into 2 groups: control (N = 69) and Rg1 (N = 69). Rg1 (0.1 mg/kg per day) were orally supplemented from 6 months of age until natural death. Spontaneous mobility was measured by video-tracking together with body composition (dual energy x-ray absorptiometry) and inflammation markers at 5, 14, 21, and 28 months of age. Results No significant differences in longevity (control: 706 days; Rg1: 651 days, p = 0.77) and tumor incidence (control: 19%; Rg1: 12%, p = 0.24) were observed between the two groups. Movement distance in the control group declined significantly by ∼60% at 21 months of age, together with decreased TNF-α (p = 0.01) and increased IL-10 (p = 0.02). However, the movement distance in the Rg1 group was maintained ∼50% above the control groups (p = 0.01) at 21 months of age with greater magnitudes of TNF-α decreases and IL-10 increases. Glucose, insulin, and body composition (bone, muscle and fat percentages) were similar for both groups during the entire observation period. Conclusion The results of the study suggest a delay age-dependent decline in physical vitality during late life by lifelong Rg1 consumption. This improvement is associated with inflammatory modulation. Significant effects of Rg1 on longevity and tumorigenesis were not observed. |
| Databáze: | OpenAIRE |
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