Synthesis and biological properties of water-soluble polyphenylthiophene brushes with poly(ethylene glycol)/polyzwitterion side chains
| Autor: | Changren Liu, Weizhi Chen, Cheng Li, Xiqun Jiang, Zhengkui Zhang, Yajun Zhang, Wei Wu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Poly ethylene glycol
Morphology (linguistics) Polymers and Plastics Chemistry Organic Chemistry Bioengineering 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry Fluorescence 0104 chemical sciences chemistry.chemical_compound Water soluble Chemical engineering Biological property Polymer chemistry PEG ratio Side chain 0210 nano-technology Ethylene glycol |
| Zdroj: | Polymer Chemistry. 8:1672-1679 |
| ISSN: | 1759-9962 1759-9954 |
| DOI: | 10.1039/c6py01941b |
| Popis: | Two types of water-soluble molecular brushes with a poly(3-phenylthiophene) (PPT) backbone tethering poly(ethylene glycol) (PEG) and zwitterionic poly(carboxybetaine) (PCB) side chains were synthesized and named PPTPEG and PPTPCB, respectively. Atomic force microscopy observations demonstrated their wormlike morphology with a length range of 5–33 nm. The two types of molecular brushes had similar emission spectra covering 500–800 nm with a maximal emission wavelength of about 590 nm in water. The fluorescence signals falling in 650–800 nm could penetrate deeper in tissues and improve the imaging properties of the brushes when they were used as optical probes. PPTPEG and PPTPCB brushes could be internalized by cells through caveolae-mediated endocytosis. The effects of PEG and PCB side chains of the brushes on their biological properties were compared, showing that the PCB side chain was favorable to the cellular uptake, tumor penetration and tumor targeting of the molecular brushes. |
| Databáze: | OpenAIRE |
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