Effect of Isoosmolar volume Reduction during Hemofiltration on Plasma Antidiuretic Hormone in Patients with Chronic Renal Failure
| Autor: | R Skowsky, A Warner, Nosratola D. Vaziri |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 030232 urology & nephrology Biomedical Engineering Medicine (miscellaneous) Bioengineering 030204 cardiovascular system & hematology Biomaterials 03 medical and health sciences 0302 clinical medicine Internal medicine Hemofiltration medicine Volume reduction In patient integumentary system urogenital system business.industry General Medicine Ultrafiltration (renal) Endocrinology Mean blood pressure Blood pressure business hormones hormone substitutes and hormone antagonists Hormone Antidiuretic |
| Zdroj: | The International Journal of Artificial Organs. 3:322-325 |
| ISSN: | 1724-6040 0391-3988 |
| DOI: | 10.1177/039139888000300605 |
| Popis: | The effect of isoosmolar volume reduction on plasma ADH level was studied in 8 patients with chronic renal failure utilizing hemofiltration technique. Plasma ADH fell significantly (P < 0.001) after one hour of hemofiltration despite volume reduction which was expected to elevate the ADH level. After two hours of hemofiltration, ADH remained low in 5 patients and increased in 3. Posthemofiltration mean blood pressure was generally lower in patients whose ADH rose than those whose ADH remained low. The two groups were otherwise comparable with respect to total fluid loss, hemofiltration rate, and fluid removed expressed as percent body weight. It can thus be suggested that in these patients a rise in plasma ADH in response to fluid reduction may require a fall in the arterial blood pressure below a critical level. While the rise in plasma ADH observed with continued fluid removal in some patients can be readily explained, we have no clear explanation for the paradoxical initial fall of ADH in all patients and subsequent maintenance of low levels observed in the majority of patients. This unusual ADH response to isoosmolar volume reduction may represent some unidentified mechanism of ADH regulation in patients with end-stage renal disease. |
| Databáze: | OpenAIRE |
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