Preterm to term infant postmenstrual age reference intervals for thyroid-stimulating hormone and free thyroxine

Autor: Herveen Singh, Dustin R. Bunch, Pablo J. Sánchez, Jonathan L. Slaughter, Monika Chaudhari, George M. Ziegler
Rok vydání: 2021
Předmět:
Zdroj: Pediatric Research. 91:1130-1135
ISSN: 1530-0447
0031-3998
DOI: 10.1038/s41390-021-01838-3
Popis: BACKGROUND Infants born preterm are affected by a hypothalamic-pituitary-thyroid axis that is immature and still developing as they progress closer to corrected term gestation. Multiple risk factors place preterm infants at risk for a hypothyroid state. However, there is variability in thyroid-stimulating hormone cutoff values and limited data on free thyroxine reference intervals to guide clinicians. METHODS 1584 thyroid-stimulating hormone and 1576 free thyroxine laboratory samples that were originally collected to screen hospitalized infants for delayed-onset of hypothyroidism were retrospectively evaluated from a group of 1087 infants who ranged in postmenstrual age from 25 to 43 weeks gestation at the time of laboratory sample collection. Median thyroid hormone values and reference intervals were established using R and the mixtools package. RESULTS Thyroid-stimulating hormone reference intervals remained similar across gestational ages from 0.340-9.681 µIU/mL in 25-27 6/7-week infants to 1.090-7.627 µIU/mL in 40-43-weeks infants. For the same age groups, free thyroxine reference intervals increased from 0.42-0.91 ng/dL to 0.87-1.32 ng/dL. CONCLUSION The reference intervals identified suggest that infants
Databáze: OpenAIRE
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