Protein S activity in sickle cell anaemia patients in steady state and crisis
| Autor: | Ebele Uche, Olufunto Kalejaiye, Festus Olowoselu, Timothy Ekwere, Rafatu Bamiro, Abdulateef Kareem, Benjamin Augustine, Odebiyi Hassan, Abdulhafeez Balogun, Akinsegun Akinbami |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International Journal of Scientific Reports. 9:5-10 |
| ISSN: | 2454-2164 2454-2156 |
| DOI: | 10.18203/issn.2454-2156.intjscirep20223370 |
| Popis: | Background: In sickle cell anaemia, there is an ever-present risk for haemostatic abnormalities which may result in reduced levels of naturally occurring coagulation inhibitors. Protein S is a Vitamin-K dependent, γ-carboxy glutamic acid-containing glycoprotein that potentiates the action of protein C when activated resulting in anticoagulation. This study measured serum Protein S activity in SCA patients during vaso-occlusive crisis and in steady-state, and this was compared with the activity in HbAA controls with a view to establishing if Protein S plays a role in VOC in SCA patients. Methods: This was an analytical prospective study comprised of 30 HbSS patients and 30 HbAA controls. Using ELISA method, Protein S levels were measured in the HbSS study group during crisis and in the HbAA control group; When the HbSS patients were in steady state, Protein S levels were also measured. Results: Protein S levels were highest in the HbAA control group (5.27+0.47 ng/ml) followed by the HbSS patients in steady state (5.08+0.56 ng/ml) and lowest in the HbSS patients in crisis (4.96+0.97 ng/ml). However, this difference was not statistically significant. Conclusions: Protein S levels are reduced in HbSS patients when compared with HbAA controls, and the levels are lower during a VOC compared with steady state. |
| Databáze: | OpenAIRE |
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