Ionic η5-Cp-Ruthenium (II) complexes as potential anticancer agents
| Autor: | Wu Xu, Frank R. Fronczek, Radhey S. Srivastava, André Delavault |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Structure analysis
010405 organic chemistry Chemistry Organic Chemistry Ionic bonding chemistry.chemical_element 010402 general chemistry Cleavage (embryo) 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Ruthenium Inorganic Chemistry chemistry.chemical_compound Toxicity Materials Chemistry Physical and Theoretical Chemistry Cancer cell lines Cytotoxicity DNA |
| Zdroj: | Journal of Organometallic Chemistry. 875:29-34 |
| ISSN: | 0022-328X |
| DOI: | 10.1016/j.jorganchem.2018.08.027 |
| Popis: | Ionic organometallic ruthenium(II) complexes, [η5-CpRu(PPh3) (1,10-phenanthroline)]+Cl− 1, [η5-CpRu(PPh3) (4,7-dimethyl, 1,10-phenanthroline)]+Cl− 2, and [η5-CpRu(PPh3) (1,10-phenanthroline-5-amine)]+Cl− 3 have been synthesized and characterized. The molecular structures of the complexes 1 and 2 were confirmed by single-crystal X-ray structure analysis. Cytotoxicity assays demonstrated that these compounds show significant toxicity against NIH3T3 and Raw 264 cancer cell lines at low concentration. These complexes have the property of DNA binding cleavage. |
| Databáze: | OpenAIRE |
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