Biochemical investigation on the localization of the cholecystokinin octapeptide in dopaminergic neurons originating from the ventral tegmental area of the rat
| Autor: | J. M. Studler, Hervé Simon, François Cesselin, J.C. Legrand, Jean-Pol Tassin, Jacques Glowinski |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Endocrine and Autonomic Systems
Chemistry digestive oral and skin physiology Dopaminergic General Medicine Striatum Nucleus accumbens digestive system Ventral tegmental area Cellular and Molecular Neuroscience Endocrinology medicine.anatomical_structure nervous system Neurology Cerebral cortex Dopamine medicine Prefrontal cortex Neuroscience hormones hormone substitutes and hormone antagonists Cholecystokinin medicine.drug |
| Zdroj: | Neuropeptides. 2:131-139 |
| ISSN: | 0143-4179 |
| DOI: | 10.1016/0143-4179(81)90062-7 |
| Popis: | This study was undertaken to verify immunohistochemical data (10,11) which have indicated that a cholecystokinin -like peptide coexists with dopamine (DA) in some neurons of the ventral tegmental area (VTA). For this purpose we examined the effects of bilateral 6-hydroxydopamine (6-OHDA) lesions of the VTA on the contents of the cholecystokinin octapeptide-like immunoreactivity (CCK 8) and DA in the anterior cerebral cortex, the nucleus accumbens and the anterior part of the striatum. Such lesions induced a selective pronounced decrease in CCK 8 levels in the posterior part of the nucleus accumbens similar to that observed for DA, confirming the presence of a composite VTA-nucleus accumbens CCK 8-DA pathway. Although CCK 8 levels in the prefrontal cortex were not affected by 6-OHDA lesions, bilateral electrolytic lesions of the VTA induced a slight significant decrease in CCK 8 levels in this cortical area. This latter result is in favor of the existence of a non-DA pathway containing CCK 8 which originate or pass through the VTA and innervate the ventral part of the prefrontal cortex. |
| Databáze: | OpenAIRE |
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