Tau protein, beta-amyloid1–42 and clusterin CSF levels in the differential diagnosis of Parkinsonian syndrome with dementia

Autor: Jan Mares, Miroslav Vastik, Jana Zapletalová, Michaela Kaiserová, Eva Hényková, Hana Přikrylová Vranová, Kateřina Menšíková, David Stejskal, Petr Kaňovský, Petr Hluštík, Miroslav Strnad
Rok vydání: 2014
Předmět:
Zdroj: Journal of the Neurological Sciences. 343:120-124
ISSN: 0022-510X
Popis: Background Parkinson's disease (PD), PD with dementia (PDD) and Lewy body dementia (DLB) are synucleinopathies. PDD and DLB are sometimes considered a transition between PD and Alzheimer dementia (AD). Finding in vivo markers or their combination could help in the differential diagnosis of these neurodegenerative (ND) diseases. Objective The aim of this study was to assess cerebrospinal fluid (CSF) levels of tau protein, betaamyloid1–42 and clusterin and to compare these levels among patients with probable PD, PDD, DLB and AD. Methods CSF levels of ND markers were assessed in 96 patients (27 patients with PD, 14 with PDD, 14 with DLB, 17 with AD and 24 subjects as a control group). Results In all of the groups of patients, beta-amyloid1–42 levels were decreasing in the order PD > PDD > DLB > AD, whereas tau protein and the tau protein/beta-amyloid1–42 index were increasing in the same order (PD Conclusion The results of the present study support the role of clusterin in PD pathogenesis. The decreasing CSF beta-amyloid1–42 levels in the order PDD, DLB and AD may relate to the increasing presence of AD pathology in these disorders.
Databáze: OpenAIRE
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